This observation is intriguing for two other explanations. initially, it suggests that cells can take up MIF by ENDOCYTOSIS. offered the considerable intracellular expression of MIF, it might be questioned what advantage would the cell achieve by utilizing endocytosed MIF in lieu of intracellular MIF. Endocytosis of MIF may well take place either i
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among the very first reviews on the MIF’s involvement in AD discovered MIF as a whole new Aβ-binding protein inside a soluble fraction of the cerebral cortex of advert brain by immunoprecipitation [73, seventy four]. Some early stories working with immunohistochemistry noted elevated expression of CD74, a MIF receptor in advert [75, seventy six]